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Adrenal cortical adenoma arising in the setting of renal–adrenal fusion: a case report and review of the literature
Journal of Medical Case Reports volume 17, Article number: 533 (2023)
Abstract
Background
Renal–adrenal fusion is a rare entity resulting from incomplete encapsulation of the adrenal gland and kidney. Only 18 cases have been reported in English literature to date.
Case presentation
Our patient is a 77-year-old African American female who presented with a systolic blood pressure of 200 mmHg. Computed tomography showed an enhancing 9 × 6 cm mass anterior and medial to the left kidney. The patient underwent a left adrenalectomy with partial nephrectomy. Gross and histologic examinations revealed an adrenal cortical adenoma and renal–adrenal fusion.
Conclusion
Renal–adrenal fusion may pose a diagnostic challenge, particularly when there is a concurrent adrenal adenoma. It is important to be aware of this uncommon anomaly to avoid misdiagnosis and overtreatment.
Background
Renal–adrenal fusion is a rare entity originally described by Rokitansky in 1855 [1]. It has been hypothesized that this anomaly is caused by failure of the retroperitoneal mesenchyme to stimulate capsule formation, thus impeding the encapsulation of the adrenal gland and kidney [2]. Renal–adrenal fusion causes no physiological symptoms, and a majority of the reported cases were discovered incidentally in nephrectomy specimens. However, renal–adrenal fusion may pose a diagnostic challenge, especially on preoperative imaging, and mischaracterization of this anomaly as a renal or adrenal malignancy can result in overtreatment.
Case presentation
A 77-year-old African American woman with a medical history of hypertension presented with a systolic blood pressure of 200 mmHg. There was no significant family or social history. A renal ultrasound showed a 12 × 9 × 7.5 cm mass medial to the left kidney. A follow-up computed tomography (CT) scan showed an enhancing 9 × 6 cm mass anterior and medial to the left kidney. Laboratory studies revealed a normal dexamethasone suppression test and an elevated androstenedione level of 182 ng/dl. Given these results, an androgen-producing adrenal tumor was suspected. The differential diagnosis also included pheochromocytoma, lymphoma, and mesenteric gastrointestinal stromal tumor. The patient underwent robotic-assisted left adrenalectomy. The intraoperative finding of “focal invasion” into the renal parenchyma raised the possibility of adrenal cortical carcinoma; therefore, an additional left upper pole partial nephrectomy was performed. The specimen received was an 11 × 7.2 × 6.8 cm adrenal mass with attached portion of kidney. The mass was golden yellow, well circumscribed, and grossly adherent to the kidney. Histologic evaluation revealed an adrenal cortical adenoma without any features of malignancy, with a Weiss score of 0 (Fig. 1). The adjacent adrenal parenchyma shared an incomplete capsule with the kidney and was in direct contact with the renal cortex, establishing the diagnosis of fusion between the two organs (Fig. 2). The postoperative course was uneventful.
Discussion
The true incidence of this anomaly is unknown. To the best of our knowledge, just 18 cases have been reported in the literature to date. Those patients and our present case are summarized in Table 1. The age of the patients ranged from 41 to 83 years old, including eight males and eleven females. Ten cases occurred on the right side, seven cases occurred on the left side, and two cases involved bilateral kidneys and adrenal glands. Due to the normal anatomical location of the adrenal gland, renal–adrenal fusion tends to occur at the upper pole of the kidney.
Renal–adrenal fusion is typically an incidental finding, since there are no clinical symptoms that are associated with this condition. A majority of reported cases were identified after surgical resection for adrenal or renal neoplasms. However, it is important to know that this rare anomaly can cause confusion on CT and magnetic resonance imaging scans, particularly when there is a concurrent adrenal adenoma, which may appear as an infiltrative mass on radiology, leading to misdiagnosis and unnecessary surgical procedures, for example, partial or even radical nephrectomy [5, 6]. Bamford et al. described that the characteristic findings on a CT scan include lack of a discrete fat plane between the upper pole of the kidney and adrenal gland, with or without a contiguous well-defined lesion within the adjacent kidney. These findings are not specific, and it is difficult to exclude an invasive renal, adrenal, or retroperitoneal lesion in unilateral cases [11]. Two of the radiologically diagnosed cases were both bilateral, and as reported by Bamford et al., the striking symmetry of the appearances and lack of suspicious uptake on positron emission tomography (PET)–CT helped to render the diagnosis [11, 13].
Renal–adrenal fusion can also pose a challenge from a surgical perspective. Boll et al. described a case of renal–adrenal fusion identified during a laparoscopic right adrenalectomy for adenoma [14]. They found that the normally avascular plane between the adrenal and renal capsule was absent, and instead, there were dense fibrotic adhesions. Those intraoperative findings may be concerning for invasive malignancy, which would require a more extensive resection. Moreover, the intraoperative frozen section of the fused adrenal tissue may be misinterpreted as renal cell carcinoma resulting in a radical nephrectomy, as reported by Fan et al. [5].
The histological diagnosis of a renal–adrenal fusion on permanent resection specimens is relatively straightforward. Findings of adherence of normal adrenal and renal parenchyma without a complete capsule allow for a confident diagnosis.
Conclusion
Renal–adrenal fusion is a rare entity. The adherence of those two organs can pose a diagnostic challenge on imaging studies and also cause confusion intraoperatively. It is important to be aware of this uncommon anomaly to avoid misdiagnosis and unnecessary resection.
Availability of data and materials
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Abbreviations
- CT :
-
Computed tomography
- PET :
-
Positron emission tomography
References
Rokitansky K. A manual of pathological anatomy, vol. Part II. Philadelphia: Blanchard; 1855. p. 199.
Honore LH, O’Hara KE. Combined adrenorenal fusion and adrenohepatic adhesion: a case report with review of the literature and discussion of pathogenesis. J Urol. 1976;115:323–5.
Ye H, Yoon GS, Epstein JI. Intrarenal ectopic adrenal tissue and renal-adrenal fusion: a report of nine cases. Mod Pathol. 2009;22(2):175–81.
Colberg JW, Cai X, Humphrey PA. Unilateral adrenal heterotopia with renal-adrenal fusion. J Urol. 1998;160(1):116.
Fan F, Pietrow P, Wilson LA, Romanas M, Tawfik OW. Adrenal pseudocyst: a unique case with adrenal renal fusion, mimicking a cystic renal mass. Ann Diagn Pathol. 2004;8:87–90.
Mahadevia S, Rozenblit A, Milikow D, Marinovich A. Renal-adrenal fusion: instance of an adrenal adenoma mimicking a solid renal mass at CT–case report. Radiology. 2009;251(3):808–12.
James B, Jeon HD, Rozenfeld M, Antic T, Kaplan EL, Angelos P, Grogan RH. Adrenal-renal fusion: a rare and challenging case for the adrenal surgeon. World J Endocr Surg. 2017;9(2):61–4.
St Clair S, Machnicki S, Yurovitsky A. Adrenal renal fusion confusion: a case report of an adrenal cortical adenoma with adrenal-renal fusion. Clin Imaging. 2015;39(4):695–8.
Patel V, Bejarano PA, Parlade A, Muruve N. Adrenal-renal fusion giving rise to an intrarenal adreno-cortical adenoma: a novel case report with review of current literature. Endocrinol Metab Syndr. 2016. https://0-doi-org.brum.beds.ac.uk/10.4172/2161-1017.1000247.
Miller C, Raza SJ, Davaro E, Cao G, Hamilton Z. Adrenal-renal fusion with adrenal cortical adenoma and ectopic adrenal tissue, presenting as suspected renal mass: a case report. Curr Urol. 2020;14(3):163–5.
Bamford R, Bretherton J, Rosenfelder N, Bell J. Bilateral adrenal-renal fusion: a radiological diagnosis. BJR Case Rep. 2018;5(2):20180108.08-12.
Basourakos SP, Dean L, Van Gurp J, Reuter V, Russo P. Pheochromocytoma arising in the setting of adrenal-renal fusion. Can J Urol. 2019;26(5):9952–5.
Schwenke M, Greene J, Braverman S, Singh M. Angiomyolipoma mimic: myelolipoma and adrenal-renal fusion. J Vasc Interv Radiol. 2020;31(6):977.
Boll G, Rattan R, Yilmaz O, Tarnoff ME. Intraoperative identification of adrenal-renal fusion. J Minim Access Surg. 2015;11(3):205–6.
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All authors contributed to the case report conception and design. The first draft of the manuscript was written by SRW, and all authors were involved in the revision of the manuscript. RM conducted the gross examination of the specimen. ST searched the literature and analyzed the manuscript. AA performed the histopathological evaluation of the slides and supervised the whole study. All authors read and approved the final manuscript.
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Wang, S.R., Morris, R., Taraif, S. et al. Adrenal cortical adenoma arising in the setting of renal–adrenal fusion: a case report and review of the literature. J Med Case Reports 17, 533 (2023). https://0-doi-org.brum.beds.ac.uk/10.1186/s13256-023-04287-0
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DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/s13256-023-04287-0