Table 2 The secondary detection of EGFR and p53 mutations by next generation sequencing in plasma and pleural effusion
Gene name | Mutation | Mutation type | Plasma abundance | Pleural effusion abundance |
|---|---|---|---|---|
EGFR | p.T490M No.20 exon Missense mutation | c.2369C > T (p.T790M) | 1.4% | 8.5% |
EGFR | p.C797S No.20 Cis-missense mutation | c.2389T > A (P.T797S) | 0.8% | – |
EGFR | p.C797S No.20 Cis-missense mutation | c.2390G > C (p.C797S) | 0.5% | 8.6% |
EGFR | p.C797S No.20 Cis-missense mutation | c.2386G > A (p.C796S) | – | 0.4% |
EGFR | p.C797S No.20 Cis-missense mutation | c.2360_2361delAginsGA (p.Q787R) | – | 8.1% |
EGFR | p.Q192*No.6 exon truncating mutation | c.574C > T (p.Q192*) | – | 6.3% |