Fig. 3

The chest and brain CT scan of before and after Osimertinib treatment. A Multiple pulmonary nodules and a cerebellar lesion had appeared in the CT scan, which indicated disease relapsed at 20 months after the initial diagnosis (white arrows). By this time the patient also received additional chemotherapy of Pemetrexed and cisplatin. EGFR-T790M is detectable in the peripheral blood. B Osimertinib treatment resulted in a partial response of the pulmonary lesions and complete response of the cerebellar lesion.