Table 1 Rapidly progressive glomerulonephritis associated with syphilis
From: Crescentic glomerulonephritis associated with syphilis: a case report and review of the literature
Age (years), sex | Symptoms | Syphilis test RPR, TPHA | BP (mmHg) | Urinary protein, sediment | ANCA GBM-Ab | Serum creatinine (mg/dL) | Pathology | Treatment | Hemodialysis | Outcomes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Walker, Am J Med, 1984 | 37, male | No skin lesion, or penile lesion, dark urine, oliguria, edema | VDRL 1:512, TP-Ab 1:16 | 180/115 | UP 4 + , RBC 100/HPF | ND | 21.6 | Cellular crescent > 90% glomeruli | mPSL pulse Plasmapheresis 3 times/week benzathine penicillin 2.4 M units/week for 4 weeks | Short-term HD | Cr 1.5–1.8, NS VDRL 1:2 | |
Nandikanti, Clin Nephrol, 2020 | 28, male | HIV + , AKI, NS, no skin lesion, no lymphadenopathy | 1:32, + | 146/78 | 4.1 g/gCr, RBC25-30/HPF. WBC 15–25/HPF | Negative | 7.2 | Necrotizing cellular crescent (6/9), segmental sclerosis (3/9), TI IF: C3 + , IgM + , EM: FPE, EDD | benzathine penicillin 2.4 M units/week for 3 weeks | (−) | Cr 1.5, UP 1.2 g/gCr, normal BP RPR 1:4 | |
Qi, BMC Nephrol 2021 | 77, female | General fatigue, polyneuropathy, anasarca, no skin lesion, AKI | -/ + , VDRL + | ND | 1.22 g/gCr, dysmorphic erythrocytes, eosinophils | Negative | 2.61 | Necrotizing crescent (9/23), TI, IF: mes C3, IgG, IgG4 in plasma cells, EM: no EDD | IV penicillin G 2 weeks mPSL 500 mg × 3 days | (−) | Cr 1.51 (1 week), Cr 1.24 (1 month), Cr 1.10 (1 year) VDRL ND | |
Present case | 62, male | Leg edema, RPGN, disappearance of skin eruption | 1:20.5, + | 177/85 | 5.87 g/gCr, many RBCs, 5–9 WBCs/HPF | Negative | 2.52 | Cellular crescent (5/24), Fibrinoid necrosis (1/24), TI | penicillin G 12 M/day 2 weeks, mPSL 500 mg × 3 days | (−) | Cr 0.96, UP 0.49 g/gCr RPR1:1.2 | |