Clinical characteristics of pneumothorax and pneumomediastinum in mechanical ventilated patients with coronavirus disease 2019: a case series

Table 3 Mechanical ventilator settings before occurrence of PTX/PM

	Mode	PEEP set, cmH2O	Plateau pressure, cmH2O	Peak pressure, cmH2O	P0.1 cmH2O ^†	PaO2/FIO2	PaCO2	Crs
1	A/C	10	21	21	ー	189	55.7	38.9
2	A/C on ECMO	15	27	27	0.5	273	34.3	15
3	CPAP + PS	10	15	15	8	138	35.1	104
4	CPAP + PS	8	14	14	1.7	207	53.9	71.2
5	A/C	10	29	29	ー	290	47.1	26.8
6	CPAP + PS	10	20	20	1	168	36.8	60.4
7	CPAP + PS	8	26	26	0.9	285	45.3	37.6
8	CPAP + PS	12	23	23	2.6	119	37	62.8
9	A/C on ECMO	12	32	32	3.8	249	46.3	50
10	A/C	12	22	22	2.1	91	44.1	55.7
11	A/C on ECMO	12	26	26	7.3	144	48.5	22
12	A/C	12	26	26	2	184	48.8	38.9
		11(10–12)	15 (12.5–17.5)	24.5 (20.5–26.5)	2.05 (1.0–3.8)	185.5 (140.9–260.8)	45.8 (36.9–48.7)	44.5 (32.2–61.6)

Three cases occurred during VV-ECMO, although they were managed under the same lung-protective settings, not lung rest settings, as recommended for ARDS. Peak pressure was 24.5 cmH2O (20.5–26.5). A high peak inspiratory pressure of 40–50 cmH2O was not detected. Respiratory effort was never strong; recorded P0.1 was 2.1 cm H2O (1.0–3.8)
Continuous variables are expressed as medians (interquartile range)
A/C assist/control, VV-ECMO venovenous extracorporeal membrane oxygenation, CPAP continuous positive airway pressure, PS pressure support, PEEP positive end-expiratory pressure, Crs total respiratory system compliance
^†P0.1 defined as the negative pressure measured at the airway opening 100 ms after the initiation of an inspiratory effort, performed against a closed respiratory circuit

ISSN: 1752-1947